MyBioSource has expanded its research reagent catalog with the addition of a validated sheep anti-rat calretinin polyclonal antibody (MBS502148), designed specifically for advanced neuroscience and cellular calcium signaling research. This antibody targets calretinin (CALB2), a crucial 29kDa calcium-binding protein predominantly expressed in neurons throughout the central nervous system, retina, and various tissues, playing essential roles in intracellular calcium buffering, cellular homeostasis, and neuroprotection.
The anti-CALB2 antibody demonstrates high specificity for the rat calretinin protein at approximately 29kDa, as confirmed by Western blot analysis of rat brain lysate. Due to 100% sequence homology, researchers can anticipate effective cross-reactivity with mouse, human, and non-human primate calretinin, expanding its utility across multiple research models and species. The antibody was developed using purified guinea pig calretinin protein as immunogen and undergoes Protein A purification to ensure high specificity and minimal background noise.
Researchers can employ this antibody across multiple validated techniques including Western Blot (WB), Immunohistochemistry (IHC) on formalin or paraformaldehyde perfused rat brain tissues, and Immunofluorescence (IF). Proper storage at -20°C with avoidance of repeated freeze/thaw cycles is recommended to maintain antibody stability and performance. For detailed product information, researchers can visit https://www.mybiosource.com.
This development holds significant implications for neuroscience research, particularly in studies focusing on neurodegeneration, calcium signaling mechanisms, auditory neuron function, and cellular calcium buffering processes. Calretinin serves as an important marker in neurological investigations, enabling analysis of calcium dynamics and neuronal resistance to excitotoxicity. The antibody's cross-species reactivity potential enhances its value for comparative studies and translational research applications.
The introduction of this specialized reagent supports academic and research institutions in elucidating fundamental mechanisms of calcium regulation, neuronal function, and related biological pathways. It contributes to the growing body of literature in neurodegeneration, auditory neuroscience, and developmental biology while advancing understanding of neuroprotective mechanisms. Researchers should note that this antibody is intended for research purposes only and is not suitable for diagnostic, therapeutic, or clinical applications, requiring appropriate laboratory safety protocols and experimental validation under specific research conditions.
