Annovis Bio Reports Buntanetap Reverses Cognitive Decline in Parkinson's Patients With Amyloid Co-Pathology

Annovis Bio Inc. (NYSE: ANVS) released new findings from its Phase 3 early Parkinson's disease study demonstrating that buntanetap halted cognitive decline across all patients and delivered the strongest benefit in those with mild dementia and amyloid co-pathology. This subgroup represents approximately 25% of the study population and typically experiences faster cognitive deterioration, but treatment with buntanetap reversed this decline while producing measurable reductions in pTau217, total tau and brain-derived tau—biomarkers associated with Alzheimer's pathology.

The data reinforce Annovis's perspective that neurodegenerative diseases often overlap and require therapies capable of targeting multiple toxic proteins, positioning buntanetap as a potentially broad-acting treatment for cognitive impairment across Parkinson's and Alzheimer's disease biology. This approach represents a significant shift from single-target therapies that have shown limited success in treating complex neurodegenerative conditions where multiple pathological proteins contribute to disease progression.

For patients with Parkinson's disease who also show amyloid pathology—a condition affecting about one-quarter of the study participants—the implications are particularly meaningful. These individuals typically face accelerated cognitive decline, but buntanetap treatment not only stopped this progression but actually reversed the cognitive deterioration. The simultaneous reduction in multiple tau biomarkers suggests the drug may be addressing fundamental pathological processes common to both Parkinson's and Alzheimer's diseases.

The full details of these findings are available in the company's official release at https://ibn.fm/CK0zo. Additional information about Annovis Bio's research and development programs can be found at https://www.annovisbio.com. The latest news and updates relating to ANVS are available in the company's newsroom at https://ibn.fm/ANVS.

This development comes at a critical time for neurodegenerative disease research, as the medical community increasingly recognizes the overlap between different forms of dementia and movement disorders. The ability of buntanetap to address cognitive impairment across disease boundaries could potentially streamline treatment approaches and improve outcomes for patients suffering from multiple neurodegenerative conditions. The reduction in established Alzheimer's biomarkers in Parkinson's patients further supports the concept that targeting shared pathological mechanisms may yield broader therapeutic benefits than disease-specific approaches.