Klotho Conference 2025 Advances Research on Protein's Role in Healthspan Extension
TL;DR
The Klotho Conference showcased new therapeutic approaches like mRNA-LNP that could give companies a first-mover advantage in the emerging longevity market.
Researchers presented Klotho's molecular pathways, clinical translation progress, and diagnostic advances from 4,390 published papers to actionable healthspan extension strategies.
Klotho research advances could extend healthy aging, reduce age-related diseases, and improve quality of life for millions through regenerative therapies.
The Klotho gene discovered in 1997 now shows potential for reversing aging effects from brain health to organ regeneration.
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The inaugural Klotho Conference & Scientific Seminar, held September 15–16 at the UCI Beall Applied Innovation Center, united leading researchers, clinicians, and innovators to discuss recent advances in Klotho biology, therapeutic potential, and diagnostic applications. This event represented a significant advancement in translating decades of Klotho research into practical strategies for healthspan extension, with presentations covering foundational science through clinical applications.
The conference opened with a "State of the Industry" address by Menachem Abraham, followed by a keynote from Dr. Makoto Kuroo, who discovered the Klotho gene. Their presentations established the current landscape of Klotho research, spanning molecular pathways to clinical translation. Research presented at the event demonstrated that low circulating Klotho levels correlate with accelerated aging and increased risk for numerous health conditions, including cancer, cognitive decline, heart failure, kidney failure, inflammation, muscle atrophy, and various age-related disorders affecting vision, hearing, skin, hair, and bone strength.
Carmela Abraham presented results of a Klotho-mRNA-LNP approach to increasing Klotho levels, while Petr Sramek shared compelling human case studies exploring Klotho-based therapies. A dedicated panel led by Dr. Dena Dubal and Dr. Miguel Chillon examined emerging evidence for Klotho's neuroprotective role, including its impact on neurodegenerative disease models and potential for gene therapy applications. Dr. Ido Wolf and Dr. Tamar Rubinek summarized research on Klotho's potential in malignant tumor suppression.
Gene therapy approaches featured prominently, with Dr. Assumpció Bosch presenting on Klotho gene therapy for ALS, outlining preclinical progress and future clinical trial roadmaps. Inflammation-focused research was another major topic, with Dr. Iliya Lefterov and Dr. Radosveta Koldamova discussing how Klotho signaling intersects with inflammatory pathways and its implications for chronic disease and aging. A panel including Dr. Mona EzzatVilinov and fitness expert Ramona Braganza explored Klotho's role in muscle regeneration, functional mobility, and exercise-driven healthspan.
Regenerative medicine applications received significant attention, with Dr. Gail Humble discussing cutting-edge research into Klotho's use in medical aesthetics covering skin, hair, and tissue regeneration. Dr. Doris Taylor presented on Klotho's regenerative applications for organs and cardiovascular tissue. Dr. Ian White delivered a keynote outlining the translational path for Klotho therapies, including how naturally derived human Klotho sources can move into clinical trial phases.
The conference featured a short highlight reel available at https://youtu.be/ngH6qERXwRI and a complete playlist of all presentations at https://www.youtube.com/playlist?list=PLIzjBuzofFehaUfXU0GdvI2X8cr3gm6SY. Attendees engaged in interactive Q&A sessions and roundtables to build collaborative pathways for Klotho research and commercialization. Several research groups indicated plans to accelerate clinical development of Klotho-based gene therapies, while the event catalyzed new partnerships among academic institutions, biotech companies, and longevity-focused investor networks.
With 4,390 papers published on Klotho since 1997, the conference reinforced the unified mission of raising Klotho biology into mainstream medical and therapeutic strategy to promote healthy aging. The success of this first Klotho Conference establishes the foundation for annual gatherings, with organizers announcing that future conferences will expand to include translational clinical trials, diagnostics development, and policy frameworks to bring Klotho therapies to patients responsibly and equitably.
Curated from Newsworthy.ai
