Creative Biolabs has announced a focus on its complement assays and microfluidic droplet generation tools, aiming to support translational researchers who require experimental systems with reliable functional readouts and controlled workflows. The company’s offerings address common challenges in complement biology and droplet microfluidics, such as assay variability, limited functional data, and inconsistent droplet formation, which can hinder data interpretation and slow research progress.
In complement-targeted drug research, understanding whether a candidate modulates pathway activity at the functional level is critical. Binding data alone may not reveal downstream biological effects, so functional assays are valuable for inhibitor characterization. To support classical pathway studies, Creative Biolabs offers a CH50 functional test kit, a hemolysis-based assay that measures the functional activity of the classical complement pathway via antibody-sensitized red blood cell lysis. The kit is designed for serum or plasma samples from multiple species, including humans, mice, and rats, and can be used in complement function studies as well as research involving complement inhibitors or activators.
For programs requiring deeper functional characterization, the company’s hemolysis inhibition profiling service uses hemolytic readouts to assess changes in complement-mediated red blood cell lysis following inhibitor treatment. By examining concentration-dependent inhibition responses, the service supports inhibitor potency assessment, comparative activity profiling, and mechanism-of-action investigations. Depending on research objectives, classical or alternative pathway assays may be incorporated to address pathway-specific questions. These functional readouts can help distinguish target-binding activity from downstream functional inhibition under defined assay conditions.
In droplet microfluidics, researchers face a different but related challenge: generating droplets with suitable consistency for encapsulation, screening, and compartmentalized assay workflows. Creative Biolabs’ flow focusing droplet generation chip uses a flow-focusing configuration in which interactions between a continuous phase and a dispersed phase promote droplet formation within microchannels. The PDMS-based chip is designed for water-in-oil and oil-in-water droplet generation and can also be applied to single-cell encapsulation research. Such systems may help researchers establish more controlled experimental conditions while adapting droplet generation parameters to specific study requirements, with potential applications in sample compartmentalization, cell encapsulation, and droplet-based screening workflows.
By providing functional complement assay solutions alongside microfluidic research tools, Creative Biolabs aims to support researchers working to refine experimental workflows, broaden functional characterization, and select research formats suited to different biological questions. All referenced products and services are intended for research use only and are not for diagnostic or therapeutic use in humans. Researchers can explore Creative Biolabs’ complement research products and services by visiting https://www.creative-biolabs.com/complement-therapeutics/.
